Abstract
AbstractDerivatives of natural dipterocarpol, dammarenolic acid and semisynthetic hollongdione were modified by the Beckman rearrangement 2 type, amination and Willgerodt ‐ Kindler reactions. The structures of new compounds were confirmed by MS, 1H‐NMR and 13C‐NMR spectroscopic analysis. Antibacterial and antifungal activities of the compounds were estimated at the University of Queensland (Australia). The result of the in vitro antimicrobial inhibitory activity revealed N‐methylpiperazinyl amide of dammarenolic acid a new lead compound with significant antifungal activity against Cryptococcus neoformans var. Grubii (MICs ≤ 0.25 μg/ml) being about ≈ 30 fold more active than the reference compound of fluconazole.
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