Abstract
BackgroundTo evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC).MethodsFifty consecutive patients with BKC and 50 age- and sex-matched healthy subjects were enrolled. Lid margin characteristics and corneal disorders were evaluated under slit-lamp illumination. Four eyelashes were collected from each eye to examine Demodex infestation by light microscopy.ResultsCorneal neovascularization (P = 0.001) and scarring (P = 0.040) were significantly worse in children than in adults with BKC, whereas meibum quality was worse in adults (P = 0.008). Diagnosis delay was longer in children with BKC than in adults (2.2 vs 1.2 years, P = 0.022). Demodex infestation was more frequent in subjects with BKC than in healthy subjects (56% vs 26%, P = 0.002). The lid margin inflammation and meibomian gland dysfunction were worse in Demodex-positive subjects than in Demodex-negative subjects with BKC.ConclusionsChildren with BKC had severer corneal disorders compared with adult BKC patients, which may be caused by a long-delayed diagnosis. Ocular demodicosis was more common in subjects with BKC. Ocular Demodex infestation was associated with worse lid margin inflammation and meibomian gland dysfunction.
Highlights
To evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC)
Demodex infestation and the clinical characteristics of BKC Demodex infestation was more frequent in subjects with BKC than in healthy subjects (56% vs 26%, P = 0.002)
In conclusion, we gave a comprehensive examination on the medical history and clinical parameters of 50 consecutive paediatric and adult BKC patients
Summary
To evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC). Blepharokeratoconjunctivitis (BKC) is a chronic and recurrent inflammatory disorder of the palpebral margin that is commonly associated with secondary conjunctival and corneal disorders [1, 2]. This disease is characterised by an inflamed lid margin (telangiectasia, thickening, and ulceration), meibomian gland dysfunction (MGD), and corneal disorders (punctate erosions, vascularisation, ulceration, and sometimes perforation) [3,4,5].
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