Abstract
The present study deals with extracellular synthesis and characterization of copper sulfide (CuS) nanoparticles using Aeromonas hydrophila, and the biological applications of the synthesized CuS like antibacterial, anti-inflammatory, and antioxidant activity were reported. Further, the toxicological effects of the CuS were evaluated using zebrafish as an animal model. The primary step of the synthesis was carried out by adding the precursor copper sulfates to the culture supernatant of Aeromonas hydrophila. The UV-visible spectrophotometer was used to characterize the synthesized nanoparticles, and the peak was obtained at 307 nm through the reduction process. Fourier transform infrared spectroscopy (FTIR) was involved to find out the functional groups (carboxylic acid, alcohols, alkanes, and nitro compounds) associated with copper sulfide nanoparticles (CuS-NPs). Atomic force microscopy (AFM) was used to characterize the CuS topographically, and a scanning electron microscope (SEM) revealed about 200 nm sized CuS nanoparticles with agglomerated structures. Overall, the characterized nanoparticles can be considered as a potential candidate with therapeutic proficiencies as antibacterial, antioxidant, and anti-inflammatory mediator/agents.
Highlights
Copper is a common element that exists naturally in the environment and distributes through anthropogenic activities
The bacterial supernatant was used for the extracellular synthesis of copper sulfide nanoparticles by adding the precursor material, mM copper sulfates thoroughly mixed and incubated for reduction process
The results have shown that CuS nanoparticles actively inhibited the heatinduced hemolysis
Summary
Copper is a common element that exists naturally in the environment and distributes through anthropogenic activities. It is soft, flexible metal with high thermal and electrical conductivity. The economic value of combining crystalline copper and semiconductor nanoparticles is used in various fields including catalysis, material science, solar cells, the environment aspects, and medicine, owing to their unique properties [1, 2]. Size, shape, and quantum effects of such reduction play a critical role in determining the properties of semiconductor nanoparticles. Like physical, chemical, and biological methods, are used to synthesize copper sulfide nanoparticles [9, 10].
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