Abstract
Sea cucumbers are a marine source with biological activities that have been used in food as well as medicine in many Asian countries. Actinopyga mauritiana is one of the sea cucumber species with limited research about its bioactive activities. In this study, the wound healing activity of A. mauritiana extract in the form of cream, gel, and serum formulations in mice was investigated. The histopathology test was performed to evaluate the fibroblast and collagen dense levels in wound healing. Phytochemical screening has been carried out by the qualitative test of alkaloids, flavonoids, glycosides, steroids, and saponins compounds. The A. mauritiana ethanol extract (SCAE) was added into cream, gel and serum formulations with various concentrations (3, 6, and 9%) and applied to the wounded area of mice. The wound healing activities and histopathology results indicated that serum 9%-SCAE performed the highest decrease of wound length 0.55 ± 0.32 compared to other groups with a density level of fibroblast and collagen are 10.00 ± 1.00 and 10.67 ± 0.00, respectively. To the best of our knowledge, this is the first report on the wound healing activity of A.Mauritiana, which demonstrated promising therapeutic agents for wound healing and cosmetics applications in the future.
Highlights
Sea cucumbers are marine invertebrates that have been consumed in Asia for centuries [1]
Since sea cucumbers have a high application to wound healing, this study aims to evaluate the wound healing potential of A. mauritiana
To the best of our knowledge, this is the first report of wound healing activities of ethanol extract of A. mauritiana sea cucumber on Mus musculus mice in cream, gel, and serum formulations
Summary
Sea cucumbers are marine invertebrates that have been consumed in Asia for centuries [1]. Sea cucumbers have attracted high attention in the biomedical field since their healing tissue capabilities due to the presence of bioactive compounds [2]. They have been used as a traditional remedy for healing wound activity in East and SouthEast Asia. Free radicals inhibit the wound healing process that leads to impaired wound healing It can disrupt dermal fibroblasts and keratinocytes functions by modifying or degrading ECM proteins. Actinopyga mauritiana is a sea cucumber present in sand lagoons and seagrasses in the shallow reefs This species belongs to the family the Holothuroidea and widely spread throughout the Red Sea to the Indo-Pacific Ocean [1], [11]. To the best of our knowledge, this is the first report of wound healing activities of ethanol extract of A. mauritiana sea cucumber on Mus musculus mice in cream, gel, and serum formulations
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