Evaluation of vitamin D receptor expression in uterine leiomyoma and nonneoplastic myometrial tissue: a cross\u2010sectional controlled study

Alesse Ribeiro Dos Santos,Walberto Monteiro Neiva Eulálio Filho,Menandro Lima De Medeiros,Maria Simone Oliveira Lima,Antônio Gilberto Albuquerque Brito,Jerusia Oliveira Ibiapina,Benedito Borges Da Silva,Emerson Davi Do Nascimento Brazil,Pedro Vitor Lopes Costa

doi:10.1186/s12958-021-00752-x

Alesse Ribeiro Dos Santos, Walberto Monteiro Neiva Eulálio Filho + Show 7 more

Open Access

https://doi.org/10.1186/s12958-021-00752-x

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Abstract

BackgroundUterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. At present, uterine myomas are the most common indication for hysterectomy because of the morbidity they cause, including intense bleeding, compression of adjacent organs, pain, and infertility. Some studies show that vitamin D receptor (VDR) expression is correlated with the etiology of uterine leiomyomas. This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue.Methods A controlled cross-sectional study involving 40 women who underwent abdominal hysterectomy the Department of Gynecology of the Getúlio Vargas Hospital of Federal University of Piauí, Brazil, was performed to compare the immunohistochemical expression of VDR in samples of uterine leiomyoma tissue with adjacent nonneoplastic myometrial tissue. The mean percetages of stained nuclei in the two groups was compared by Student’s t teste, with significance established at p < 0.05.ResultsThe percentage of cells with nuclei stained by anti-VDR in the myometrial and leiomyoma tissue was 79.52 % (± 4.32) and 60.22 % (± 7.24), respectively (p < 0.0001).ConclusionsThe mean percentage of nuclei expressing VDR was significantly lower in the uterine leiomyoma than in nonneoplastic myometrial tissue.

Highlights

Uterine leiomyomas are the most frequent benign solid pelvic tumors in women of reproductive age [1]
There was no statistical correlation of expression of vitamin D receptor expression in uterine leiomyoma tissue with age, parity, tumor size, uterine volume or nutritional status (Table 3)
In this study, we evaluated the expression of the biomarker vitamin D receptor (VDR) in human uterine leiomyoma tissue and compared it that in nonneoplastic myometrial tissue

Summary

Introduction

Uterine leiomyomas are the most frequent benign solid pelvic tumors in women of reproductive age [1]. They are usually detected between 30 and 40 years of age [2]. Uterine leiomyomas are characterized by excessive extracellular matrix (ECM) deposition as well as an increase in cell proliferation [7]. Uterine myomas are the most frequent benign solid pelvic tumors in women of reproductive age. This study aimed to assess the expression of VDR in uterine leiomyoma and nonneoplastic myometrial tissue

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