Evaluation of Vitamin D Fractions in Obese Hypertensive Patients.

Marta Pelczyńska,Paweł Bogdański,Krystyna Czyżewska,Teresa Grzelak,Matylda Kręgielska-Narożna,Marcelina Sperling

doi:10.3390/ijerph17051660

Abstract

Vitamin D fractions can be involved in the pathogenesis of metabolic disorders, but their concentrations are rarely determined. The aim of this study was to evaluate the concentration of vitamin D fractions in obese hypertensive patients and to determine its associations with anthropometric parameters, glucose levels, and lipid profiles. A total of 85 obese hypertensive patients (OBHT) and 40 nonobese nonhypertensive subjects (NOBNHT) underwent biochemical measurements of lipid profiles, glycemia, 25-hydroxyvitamin D (25(OH)D), free vitamin D (free25(OH)D), vitamin D binding protein, albumin levels. Moreover, free25(OH)D and bioavailable25(OH)D (bio25(OH)D) concentrations were calculated. Blood pressure and anthropometric measurements were performed. Differences between groups (p < 0.001) were found for 25(OH)D (OBHT 40.25 ± 18.02 vs. NOBNHT 64.10 ± 22.29 nmol/L), free25(OH)D (9.77 (7.46; 11.49) vs. 13.80 (10.34; 16.82) pmol/L), bioavailable 25(OH)D (3.7 (2.8; 4.4) vs. 5.4 (4.2; 6.7) nmol/L), and calculated free25(OH)D (7.82 (5.54; 11.64) vs. 10.46(8.06;16.28) pmol/L, p = 0.002). The OBHT patients showed no relationship between vitamin D fractions concentration and glucose or lipids level, although it was associated with anthropometric parameters. In the NOBNHT group, vitamin D fractions correlated positively with HDL cholesterol and negatively with triglyceridemia and hip circumference. Vitamin D fractions were decreased in obese hypertensive subjects, and were associated with anthropometric parameters, but not with glucose level or lipid profiles; they thus cannot be considered as a predictive marker of metabolic disorders in this group of patients.

Highlights

Excessive body weight is perceived as an independent risk factor for the development of hypertension, and the population of obese hypertensive people continues to increase
Vitamin D fractions were decreased in obese hypertensive subjects, and were associated with anthropometric parameters, but not with glucose level or lipid profiles; they cannot be considered as a predictive marker of metabolic disorders in this group of patients
From the clinical point of view, such measurements would give more complete information on vitamin D status [17], which we have demonstrated in our previous study of patients with metabolic syndrome [18]

Summary

Introduction

Excessive body weight is perceived as an independent risk factor for the development of hypertension, and the population of obese hypertensive people continues to increase. Particular attention has been paid to the role of vitamin D fractions in the pathogenesis and the course of obesity. It is believed that a decreased serum concentration of vitamin D fractions is associated with a higher risk of metabolic disorders, such as insulin resistance and dyslipidemia, in this group of patients. One factor that affects vitamin D concentration is the amount of visceral adipose tissue, which sequesters this vitamin, affecting its concentration in the blood [1,2]. Res. Public Health 2020, 17, 1660; doi:10.3390/ijerph17051660 www.mdpi.com/journal/ijerph

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