Abstract
Background: Periodontitis is an inflammatory disease that affects the periodontium, which is the protective apparatus that surrounds a tooth and includes the gingiva, alveolar bone, cementum, and periodontal ligament and is initiated by bacterial infection, subsequently progresses because of altered host response, and causes periodontal tissue destruction. These bacteria have the capacity to destroy the collagen fibres and ground substance directly by releasing virulence factors like enzymes - collagenase and toxins - gingipains. Indirectly act on various receptors like toll receptors and activate host immune response. Some immune cells like neutrophils, start producing reactive oxygen species (ROS). Vitamin C acts as an antioxidant, by acting as an electron donor Thereby preventing lipid peroxidation by ROS. Vit. C also controls collagen synthesis by directly activating collagen synthesis transcription and stabilizing procollagen mRNA. Along with other properties, Vitamin C is said to have anti-inflammatory and wound healing properties. Aim: This study aimed to systematically review to assess the effect of Vitamin C, as an adjunct to periodontal therapy.
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