Evaluation of Vitamin A and e levels in Chronic Renal Failure

Abstract

Any atom or molecule that contains one or more unpaired electrons is defined as free radical, the most known reactive species. An unpaired electron is an electron that occupies an orbital alone, but electrons usually associate in pairs in orbital's of atoms and molecules. The present study focuses on the extent of free radical damage on lipid and Lipid peroxidation end products (measured as malondialdehyde, MDA) and effect on antioxidant defense mechanism (measured as vitamin E and vitamin C in the serum of CRF patients predialytically. The study was Carried in Sri Lakshmi narayana Institute of Medical Sciences, Pondicherry. 50 cases and 50 controls between age group of 30–60 were taken. Lipid peroxidation was measured in terms of MDA and antioxidants were measured as vitamin E and Vitamin C in serum of CRF patients before dialysis. The level of MDA, serum urea and Creatinine was significantly increased, antioxidant vitamin levels (C and E) were decreased in CRF patients as compared to normal subjects. Though there is evidence for production of oxygen free radicals in CRF, reports on net oxidative imbalance in the uremic state, as evidenced by increase in oxidant markers and decrease in antioxidant vitamins status in CRF patients. Oxidative injury generally takes place only when local oxidant production exceeds antioxidant defense.