Abstract
BackgroundIn the existing literature, the evidence regarding the effects of certain oils on the amelioration of hyperglycemia contains ambiguities and contradictions; and with regard to other oils, the quantity of existing studies is scant.ObjectiveTo assess the influence of sesame, garden rocket, organic olive, thyme, fenugreek, hazelnut, and cod liver oil on serum glucose, liver function, and kidney functions.MethodsMale albino rats were injected with streptozotocin (60 mg/kg BW). The duration of the experiment was 28 days. Maximum recovery of occurred wasting attributable to diabetes was found in the sesame and cod liver groups.ResultsWith respect to ameliorating and/or preventing the side effects of diabetes on liver function, this experiment showed that thyme, organic olive, cod liver, and fenugreek oils were efficacious. Turning to serum lipid profile, organic olive oil not only ameliorated but also prevented the changes of TC, HDL, LDL, and AI. Vegetable and cod liver oil diets resulted in a marked amelioration of renal dysfunction, but they were unable to prevent this side effect. Similar, oil diets were unable to mask the increase in serum glucose due to diabetes mellitus.ConclusionOn the basis of these findings, it could be recommended that when attempting oil diet treatment for the side effects of diabetes, a blend of the various specific treatments which showed best results should be employed in order to achieve improvement with respect to all parameters; and in part, this is because a synergism between the various treatments can be expected.
Highlights
The term diabetes mellitus refers to a group of metabolic disorders, all of which share one common manifestation: hyperglycemia – that is, high level of blood sugar
On the basis of these findings, it could be recommended that when attempting oil diet treatment for the side effects of diabetes, a blend of the various specific treatments which showed best results should be employed in order to achieve improvement with respect to all parameters; and in part, this is because a synergism between the various treatments can be expected
All animal procedures were performed according to the Guide for The Care and Use of Laboratory Animals of the National Institute of Health [17] and Canadian Council on Animal Care [18], and approved by Research ethics committee of King Abdulaziz University. (Reference No 1005-13).Cod (Gadus callarias) liver oil was purchased from the pharmacy while the vegetable oils were obtained from the local market of Jeddah
Summary
With respect to ameliorating and/or preventing the side effects of diabetes on liver function, this experiment showed that thyme, organic olive, cod liver, and fenugreek oils were efficacious. Turning to serum lipid profile, organic olive oil ameliorated and prevented the changes of TC, HDL, LDL, and AI. Vegetable and cod liver oil diets resulted in a marked amelioration of renal dysfunction, but they were unable to prevent this side effect. Oil diets were unable to mask the increase in serum glucose due to diabetes mellitus
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