EVALUATION OF VEDANASTHAPANA (ANALGESIC) EFFECT OF MOCARASA: SHALMALI NIRYASA (SALMALIA MALABARICA – GUM DC)

Abstract

Pain, said to be one of nature’s earliest signs of morbidity and is also one of the most typical presentations seen in medical practice, brings disturbance in the equilibrium state of a person. In order to manage such conditions, several drugs are available in the present era. Among them, some are expensive, and some have side effects such as dyspepsia and gastrointestinal bleeding, burning sensations, etc. For relieving pain, Acharya Charaka mentioned Vedanasthapana Daseimani Gana (Group of 10 Drugs), of which Mocarasa (Salmalia malabarica Dc.) is one among them. This study is taken up to evaluate the Vedanasthapana (Analgesic) karma of Mocarasa on albino mice using Eddy’s hot plate method. The Eddy’s Hot plate method is followed with three groups of Albino mice (6 mice in each group) as control group, standard drug group and trial drug group. Distilled water is fed to the control group, Mocarasa kwatha (decoction) for the trial drug group and Diclofenac sodium for the standard drug group. Statistically, the analgesic effect in the trial drug started gradually at 60 min and continued up to 120 min. Meanwhile, the standard group showed immediate onset of action at 15 min duration and progressively increased up to 120 min. The trial drug and the standard drug showed insignificant differences, which reveals that both have similar analgesic activity.