Evaluation of Using Platelet Rich Fibrin Versus Collagen Membrane for Enhancing Healing of Secondary Grafted Alveolar Cleft: A Randomized Controlled Trial

Abstract

PurposeThe purpose of this study was aimed to compare the efficiency of using autologous platelets rich fibrin versus a resorbable collagen membrane in secondary alveolar bone grafting. Materials and methodsPatients were randomly allocated to the three treatment groups; group (1) twelve children in whom nasal layer of alveolar cleft were repaired using autologous platelet rich fibrin with autogenous chin bone, group (2) twelve children in whom nasal layer of alveolar cleft were repaired using Bovine collagen membrane type I (Colla-D) with autogenous chin bone, and group (3) twelve children in whom bony alveolar cleft was grafted with autogenous chin bone after construction of watertight nasal floor was completed. ResultsThe study population comprised thirty-six patients with alveolar clefts, Patients ranging in age from (7 to 12 years). At the last follow up period all groups had stable healing conditions, good and radiological outcomes in terms of alveolar bone height bordering the teeth mesially and distally, as well as the incorporation of the graft material with the surrounding bone. ConclusionThe use of a PRF membrane and a collagen membrane as an interposition layer between the nasal layer and the autogenous chin bone graft enhanced bone formation and density in alveolar clefts compared to the control group.