Abstract
<p><strong>BACKGROUND</strong><strong>: </strong>Oral lichen planus (OLP) is a chronic and inflammation mucosal disease. Reactive Oxygen Species (ROS) and oxidative stress damage might be the cause. Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease.</p><p><strong>OBJECTIVE</strong><strong>: </strong>To evaluate antioxidants and oxidative stress parameters in patients with oral lichen planus (OLP) diseases and healthy control group with compare on serum and salivary samples.</p><p><strong>MATERIAL </strong><strong>&amp;</strong><strong> METHODS: </strong>The research population included 22 patients with OLP which recently diagnosed and 22 healthy controls matched for periodontal status. Total antioxidant activity (TAA), Malondialdehyde (MDA) or lipid peroxidation product and uric acid (UA) were evaluated in both serum and saliva. The t-tests were used for differences between the two groups in normal distributed variables and also Spearman’s rho correlation coefficient for assessing association between serum and salivary fluids.</p><p><strong>RESULTS</strong><strong>: </strong>TAA levels in OLP patients showed significant result and lower than healthy control group (p=0.39). Also, results in the saliva MDA concentration, was significantly higher in OLP patients than controls. In correlation test, inverse and significant correlation was observed between the MDA and UA values(r=0. 682, P=0.0001) and a significant correlation was found between serum TAA and UA values.</p><p><strong>CONCLUSION</strong><strong>: </strong>This study showed that OLP groups have higher cellular lipid peroxidation in compare to healthy controls and low level of TAA than controls. Patients with OLP are believed to be more at risk of antioxidant-oxidative stress imbalance.</p>
Highlights
Oral lichen planus (OLP) is common chronic, mucosal and with inflammation background disease
Inverse and significant correlation was observed between the MDA and uric acid (UA) values(r=0. 682, P=0.0001) and a significant correlation was found between serum total antioxidant activity (TAA) and UA values
A significant inverse correlation was found between serum UA and MDA values (r=0.682, P=0.0001) and a significant correlation was observed between serum TAA and UA values (r=0.586, P=0.0001).there was a significant correlation but inverse result in MDA and TAA values in serum(r=0.677, p=0.0001) and saliva (r=0.475, P=0.045)
Summary
Oral lichen planus (OLP) is common chronic, mucosal and with inflammation background disease. It is classified into cell-mediated immune state with cellular degeneration (Mishra, 2014). The first step of production of oxidative stress is the metabolic reactions that use oxygen and represent disturbance balance in pro-oxidant/antioxidant reactions in living organisms (Valko et al, 2009). It has been found ROS is produced by keratinocytes, fibroblasts and several inflammatory cells, could lead to imbalance between the pro-oxidants and antioxidants in the body (Fuchs et al, 2001). Malondialdehyd (MDA), one parameter of lipid peroxidation is appropriate for DNA damage in OLP disease
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