Abstract
Microbial exopolysaccharides (EPSs) are mostly produced by bacteria and fungi and have potentialuse in the production of biomedical productssuch asnutraceuticalsandin tissue engineering applications. The present study investigated the in vitro biological activities and in vivo wound healing effects of EPSs produced from a Sclerotium-forming fungus (Sclerotium glucanicum DSM 2159) and a yeast (Rhodosporidium babjevae), denoted as scleroglucan (Scl) and EPS-R, respectively. EPS yields of 0.9 ± 0.07g/L and 1.11 ± 0.4g/L were obtained from S. glucanicum and R. babjevae, respectively. The physicochemical properties of the EPSs were characterized using infrared spectroscopy and scanning electron microscopy. Further investigations of thebiological properties showed thatboth EPSs were cytocompatible toward the human fibroblast cell line and demonstrated hemocompatibility. Favorablewound healing capacities of the EPSs (10mg/mL) were also established via in vivotests.The present study therefore showed that theEPSs produced by S. glucanicum and R. babjevae have the potential useas biocompatible components for the promotion ofdermal wound healing.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
