Abstract
A variety of animal models have been developed to assess the efficacy of antithrombotic agents, including experimental models of venous thrombosis [1–5]. A common feature shared by experimental animal models of venous thrombosis is a trigger of the thrombogenic state, which is usually composed of two components of Virchow's triad [6]. Either hypercoagulability or vessel injury combined with a reduced blood flow may be used to achieve a thrombogenic state. From the perspective of interlaboratory comparisons, the most problematic component of achieving a thrombogenic state seems to be hypercoagulability, which is usually triggered by an intravenous injection of recombinant or animal thromboplastin [1–4].
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