Abstract
This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs® (Group 2), and 10 were grafted with BETA-TCP® (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 ± 17.4%. Group 2 presented 45.5 ± 9.9%, and Group 3 conferred 35.4 ± 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.
Highlights
Introduction iationsAlveolar bone resorption is a physiological, continual, and gradual process that occurs after tooth extraction and results in bone height or length deficiency [1–4]
The results showed a minimum of 8 formation of the three study groups: 10 maxillary sinuses grafted with autogenous bone maxillary sinuses for each group when the test was applied with a power of 80%,® a mean graft as Group 1, 10 maxillary sinuses grafted with ChronOS
Group 3 of the present study showed more biomaterial particles remaining than Group 2 after 6 months of bone healing
Summary
Alveolar bone resorption is a physiological, continual, and gradual process that occurs after tooth extraction and results in bone height or length deficiency [1–4]. In the posterior maxillary region, this issue represents a challenge for dental professionals in oral rehabilitation cases using dental implants [1,2]. With relevant results, maxillary sinus lifting surgery using biomaterials to reconstruct this area has been used to regenerate the height, allowing implant placement [3–5]. Autogenous bone graft is the “gold standard” bone substitute due to its unique possession of osteoinduction, osteoconduction, and osteogenic properties [6,7]. Autogenous bone graft harvesting requires another surgical site and creates greater morbidity, even if harvesting is from the intraoral region [8,9].
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