Abstract
The purpose of this study was to investigate the plan qualities of various treatment modalities for the radiotherapy of cutaneous Kaposi's sarcoma developed on the skin of the foot. A total of six virtual targets were generated on the skin of the foot in CT images. Five types of treatment plans were generated using photon beams (PB), electron beams (EB), high‐dose‐rate (HDR) brachytherapy with a Freiburg flap applicator, intensity‐modulated radiation therapy (IMRT), and volumetric‐modulated arc therapy (VMAT) techniques. Plans for each of the six targets (single‐target plans) and also for the combined target consisting of the six single targets combined (multitarget plans) were generated. Dose‐volumetric analysis was performed for the targets and normal tissues. The averaged conformity index (CI) and homogeneity index (HI) values for each single target using PB, EB, HDR, IMRT, and VMAT techniques were 1.97, 2.39, 1.60, 4.60, and 0.80 and 1.05, 1.11, 1.52, 1.04, and 1.04, respectively. For the multitarget, the CI values were 3.99, 5.08, 1.38, 1.95, and 0.84, and the values of HI were 1.10, 1.36, 1.43, 1.06, and 1.04, respectively. The averaged mean doses to normal tissue were 2.5, 2.7, 3.6, 1.7, and 2.9 Gy for single‐target plans, and 21.3, 14.6, 14.2, 14.3, and 13.0 Gy for the multitarget plans, respectively. The VMAT demonstrated dosimetric advantages and better treatment efficiency over other techniques for the radiotherapy of multifocal skin disease of the feet.PACS number: 87.55.dk
Highlights
174 Park et al.: Planning study for skin disease of the feetprevalence of acquired immune deficiency syndrome (AIDS).[3]
prevalence of AIDS.[3]. It has been well established that Kaposi’s sarcoma (KS) is responsive to radiation therapy, and in response various radiation treatment schemes have been studied.[1,2,3,4,5,6,7,8,9,10,11,12,13] The response rate of KS in epidemic form to radiation therapy has been demonstrated to be as high as 90%, and it has been proven that radiation therapy shows better symptomatic control than chemotherapy.[14]
This study demonstrated that total disappearance of the skin lesions was achieved in 89% of the patients; the limb edema regressed completely in only 56% of the patients[1] due to reduced lymphatic drainage.[15]. In order to relieve edema, electron beam therapy could be implemented as an alternative treatment for extremity KS
Summary
This study demonstrated that total disappearance of the skin lesions was achieved in 89% of the patients; the limb edema regressed completely in only 56% of the patients[1] due to reduced lymphatic drainage.[15] In order to relieve edema, electron beam therapy could be implemented as an alternative treatment for extremity KS. Nicolini et al[15] proposed volumetric-modulated arc therapy (VMAT) with a natural wax bolus on the extremities as a treatment modality for extremity KS. They compared VMAT plans for lower extremities with electron beam plans and concluded that VMAT was superior to electron beam therapy. Cutaneous KS developed at extremities has been studied, no study far has been performed for the treatment of cutaneous KS developed on the skin of the foot
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
