Abstract

Pneumonia is one of the common complications of SARS-CoV-2 infection where most patients have moderate to severe symptoms that pose a higher risk for death. This study aims to evaluate the treatment outcome of COVID-19-associated Pneumonia among patients with/without comorbidity in a public hospital in Indonesia. This is a retrospective cohort study involving unvaccinated confirmed COVID-19 patients admitted to the hospital between March and December 2020. All confirmed COVID-19 patients with Pneumonia (n = 1522) treated at the hospital were included. The majority of patients (99%) had mild COVID-19 symptoms while the remaining had moderate symptoms. The median age was about 32 years old and the average treatment duration was 6.25 ± 1.83 days. Most patients (88.8%) received a combination of azithromycin and oseltamivir. There was a very significant relationship (p < 0.001) between comorbidities with treatment and duration of treatment of Pneumonia in COVID-19 patients. Although most patients had Pneumonia and comorbidities, they were successfully treated with azithromycin and oseltamivir combination following approximately five days of treatment.

Highlights

  • Several coronaviruses cause respiratory tract infections in humans ranging from coughs and colds to more serious ones [1]

  • We aim to evaluate the treatment outcome for Pneumonia among pre-vaccinated COVID-19 patients with/without comorbidity in a public hospital in Bengkulu, Indonesia

  • This is a retrospective cohort study involving 1522 laboratory-confirmed COVID-19 patients admitted to the green zone area at a public hospital, Bengkulu

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Summary

Introduction

Several coronaviruses cause respiratory tract infections in humans ranging from coughs and colds to more serious ones [1]. The symptoms experienced are usually mild and appear gradually and some infected individuals may not show any signs and still feel healthy [1]. WHO officially declared COVID-19 as a pandemic on Wednesday, 11 March 2020 and the cases have been increasing ever since. According to the WHO, a pandemic is the scale of the spread of a condition globally throughout the world, including in Indonesia [2,3]. The Indonesian Ministry of Health recorded an increase in positive cases of COVID-19 on 5 November 2021, bringing the total to 4,246,802. The Ministry of Health has examined 47,709,218 specimens, with a cure rate of 84.0%. The cases of death with confirmed COVID19 increased to 143,500 cases [4]

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