Abstract
BackgroundTraumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. However, there is paucity of information regarding changes in the physiologic state of humans or animals after brain shaking.MethodsIn this study, near-infrared spectroscopy (NIRS) was used to continuously monitor the concentration change of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) to understand changes in the physiological state during and after brain shaking. Laser Doppler flowmetry was also used to monitor changes in cerebral blood flow under TBI to supplement the investigation. Triphenyltetrazolium chloride (TTC) staining was used to monitor changes of infarction volume corresponding to different impact strengths.ResultThe experimental results indicated that concentration changes of HbO2 and total-hemoglobin (HbT) were significantly related to the impact strength. The infarction volume was also significantly related to the impact strength.ConclusionTherefore, the non-invasive monitoring of concentration changes in HbO2, HbR, and HbT using NIRS may have a clinical application for the evaluation of TBI.
Highlights
Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death
Conclusion: the non-invasive monitoring of concentration changes in HbO2, HbR, and HbT using near-infrared spectroscopy (NIRS) may have a clinical application for the evaluation of TBI
Variation of cerebral blood oxygenation under traumatic brain injury The randomly selected experimental result for the temporal profiles of Δ[HbO2], Δ[HbR], and Δ[HbT] in ipsilateral side and contralateral side during and after fluid percussion injury (FPI) experiment, with the impact strength set to 1.6 a.t.m., were shown in Fig. 2a and Fig. 2b, respectively
Summary
Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. Traumatic brain injury (TBI) is often caused by brain shaking or impact. It affects the normal brain function and may lead to disability or death. For severe TBI (GCS 3–8), patients may be unconscious and cannot open eyes or follow orders [2]. They are at high risk for hypoxemia or brain edema and have 30 % mortality in the first three days [3]
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