Evaluation of transfer media containing different concentrations of hyaluronan for human in vitro fertilization

Abstract

PurposeThe aim of the present prospective study was to investigate the efficacy of hyaluronan (HA) using two different concentrations as embryo transfer media for in vitro fertilization embryo transfer cycles.MethodsA total of 169 cycles undergoing fresh embryo transfer on day 2 or 3, 561 cycles undergoing frozen‐thawed embryo transfer on day 2 or 3, and 484 cycles of frozen‐thawed blastocyst transfer were included in this study. Patients were randomly divided into two groups: transferred with low (l‐HA) or high (h‐HA) concentrations of HA in transfer media.ResultsIn the case of fresh embryo transfer cycles, no significant differences were observed in the pregnancy (l‐HA 27.2%, h‐HA 31.2%), implantation (l‐HA 22.1%, h‐HA 24.2%), or abortion (l‐HA 24.0%, h‐HA 20.8%) rates between the two groups. In the case of frozen‐thawed embryo transfer cycles, no significant differences were noted in the pregnancy (l‐HA 20.9%, h‐HA 22.9%), implantation (l‐HA 13.4%, h‐HA 15.8%), or abortion (l‐HA 17.2%, h‐HA 21.5%) rates. In the case of frozen‐thawed blastocyst transfer cycles, no significant differences were observed in the pregnancy (l‐HA 46.0%, h‐HA 41.8%), implantation (l‐HA 45.8%, h‐HA 41.3%), or abortion (l‐HA 17.6%, h‐HA 26.9%) rates.ConclusionThe present results showed that pregnancy, implantation, and abortion rates with transfer media containing different HA concentrations were similar.