Abstract
Transfer factor has been prepared from sensitized guinea pigs against heatkilled Mycobacterium bovis antigen and protective efficacy were evaluated inguinea pigs that gave 1 ml of transfer factor equivalent 5x108 cell / ml of sensitizedand normal cell donor; then challenged with dose 0.01 mg / animal of virulentMycobacterium bovis, After 40 days of challenge all animals were sacrificied.Histologically: - TFs recipient group showed a mono-nuclear cellsinfiltration’s (Lymphocytes & Macrophages) with a mild emphysema of lungs, andliver showed mononuclear cells ,a small necrotic foci in the lymphocytic organs(spleen & lymph nodes); the kidney showed mononuclear cells in glomeruli andurinary tubules ;While the TFn recipient group were an areas of caseated necroticmaterials surrounded by macrophages &Lymphocytes, congestion of internalorgans (Liver and Spleen) and Sever congestion with hemorrhage of alveoli tissue,sever emphysema & consolidation in lung kidney showed tuberculle foci inglomeruli and around urinary tubules .There were no pathgenomic changes in heart muscles of TFs recipient group whilea mild congestion in TFn recipient group.
Highlights
Tuberculosis (TB) is a chronic zoonotic disease that causes major health problems on global scale of human and animals
Histologically: - TFs recipient group showed a mono-nuclear cells infiltration’s (Lymphocytes & Macrophages) with a mild emphysema of lungs, and liver showed mononuclear cells,a small necrotic foci in the lymphocytic organs; the kidney showed mononuclear cells in glomeruli and urinary tubules ;While the TFn recipient group were an areas of caseated necrotic materials surrounded by macrophages &Lymphocytes, congestion of internal organs (Liver and Spleen) and Sever congestion with hemorrhage of alveoli tissue, sever emphysema & consolidation in lung kidney showed tuberculle foci in glomeruli and around urinary tubules
There were no pathgenomic changes in heart muscles of TFs recipient group while a mild congestion in TFn recipient group
Summary
Tuberculosis (TB) is a chronic zoonotic disease that causes major health problems on global scale of human and animals. Human tuberculosis accounts for 8 million cases of clinical disease with 3 million deaths annually (1). The reports of WHO estimated that in 1990 about 1.7 million people (one third of world population) infected with tubercle bacilli Bovine (2) tuberculosis causes a major economic loss. A transfer factor is a dialyzable moiety obtained from immune lymphocytes successfully used for treatment of several infections viral (5); bacterial (6); fungal (5); internal parasites (7) and neoplastic diseases (8). The aim of this study is to use transfer factor as an immunotherapy protection against tuberculosis in guinea pigs
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