Evaluation of Tolerance and Trichological Efficacy of a Food Supplement in Men and Women with Telogen Effluvium-like Disorder

Abstract

Hair thinning is a very common problem in dermatology, affecting both men and women, and can strongly impact the quality of life of subjects. In this view, therapies that aim to reduce the appearance of thinning by delaying, arresting, or reversing the course of hair thinning are highly desirable. A novel nutraceutical product (NS) containing active botanicals, a patented composition comprising rutin and polyunsaturated fatty acids (PUFAs), zinc, biotin, and ornithine, has been developed to improve hair growth in subjects with hair thinning. Sixty subjects with telogen effluvium-like hair loss were randomized 1:1 in two groups (NS vs. placebo) and treated for three months and evaluated at the baseline visit (T0), and after 15 days (T1) and one (T2), two (T3), and three (T4) months of treatment. Two follow-up visits one month (T5) and two months after the last assumption (T6) were also included in the protocol. Subjects were evaluated for the percentage of hair in the anagen phase, density of hair in the anagen phase (n/cm2), vellus hair (miniaturized, smaller, and thinner hair), and the entity of hair loss in the telogen phase (pull test). NS supplementation produced a statistically significant (p < 0.05) increase in anagen hair and hair density versus baseline from 15 days (T1) of treatment and this effect was not detectable for placebo. Moreover, a clinically/statistically significant (p < 0.05) decrease in vellus hair was also reported, suggesting not only a rapid reduction of the process of miniaturization of the hair but also a transformation of vellus hair into terminal hair. The NS treatment also showed a significant (p < 0.05) increase in tensile strength till T6 (vs. placebo). A higher percentage of subjects who took the NS noted a reduction in daily hair loss, an increase in brightness, and the presence of stronger hair. No side effects were reported. The present study confirms the clinical efficacy and safety of novel nutraceutical supplements in men and women with hair thinning, acting as a multi-targeted therapeutic approach to hair thinning due to TE-like phenomena.