Evaluation of TNF? in Patients with Heart Failure According to BNP Concentration

Abstract

Background: Heart failure (HF) is a condition in which the heart can no longer pump blood as efficientlyas it used to. This is lead to a complex of clinical symptoms like (dyspnea, orthopnea, lower limb swelling).BNP is a neurohormone released from myocardium and increased when failure of heart is occure and usedfor diagnosing heart failure. TNF? is pro inflammatory cytokine, its concentration increasing in patients withheart failure, this caused by inflammation which is present in heart with failure.Objectives: This study was designed for Examining serum concentrations of TNF? in patients with HF,examining whether this cytokines was involved in the pathophysiology of the HF syndrome, and investigatingthe effectiveness of using BNP concentration as an indicator for heart failure.Subjects and Method: The current study is a cross sectional study that was carried out in the center ofDiyala province, Baquba Teaching Hospital, to determine the serum concentration of BNP and TNF-? inpatients with heart failure. The samples were collected in 2 and a half months, from January the 15th toAprilthe 1st 2019.A total of 150 serum samples were collected . 100 patients with diagnosed heart failure, and the restapparently healthy. The age range was 30-89 years, 50 of them were males, and 50 were females. BNP andTNF? concentrations were tested in the serum samples using the BNP and TNF? ELISA kit (from Sun Redcompany - China).Human privacy was respected by taking the parents’ verbal consent. Statistical analysisof data was carried out using the Statistical Packages for Social Sciences (SPSS), Version 25. Statisticalsignificance was considered whenever the P value was equal to or less than 0.05.Results: The results showed that the BNP concentration range in HF group patients (50-1600) was widerthan that in healthy control group (5-160) with a statistically significant difference between HF groupand healthy control group(P = 0.0001).Also there is statistically significant association between TNF?concentration and HF (P = 0.005). Furthermore, there was no statistically significant effect of age andgender on TNF-? concentration in neither the diseased group nor the control group. Also there is statisticallysignificant relationship between TNF? and family history (P = 0.026). There is direct relationship betweenTNF? and HF grade with a P value of 0.0001.Conclusion: The concentration of TNF? is elevated with increasing the severity of heart failure accompaniedby BNP concentration elevation, where Theincrease the HF grade, the elevation the concentration of TNF?.