Abstract
Background. Various treatment modalities, such as leucocyte platelet-rich fibrin (L-PRF), bone grafts, and membranes, have been used for the restoration of lost periodontal tissues. Titanium-prepared platelet-rich fibrin (T-PRF) has attracted attention for its proper haemocompatibility, thick fibrin meshwork, and long resorption time. The present study aimed to evaluate the effectiveness of T-PRF and L-PRF in the management of intra-bony defects based on clinical and radiographic criteria. Methods. Twenty-six subjects with 34 intra-bony 3- walled defects were divided into two groups (n=17) and treated with T-PRF or L-PRF. Clinical and radiographic measurements were recorded at baseline and 6- , 3- and 9- month intervals and tabulated on Microsoft Excel spreadsheets. For intra- and intergroup comparisons, paired and unpaired t-tests were performed. P<0.05 was set as statistically significant Results. Intra-group comparisons revealed statistically significant differences (P<0.05) from baseline in both groups regarding clinical measurements. On intergroup comparison, the T-PRF group exhibited a significantly higher defect fill compared to the L-PRF group (P<0.05). Conclusion. Within the limits of the present study, T-PRF seems to be a better alternative to L-PRF in the treatment of intra-bony defects.
Highlights
Periodontitis is a multifactorial inflammatory disease destroying the hard and soft tissues of the periodontium.[1]
Since only a limited number of comparative randomized clinical trials have been conducted on Titanium-prepared platelet-rich fibrin (T-PRF) and leucocyte platelet-rich fibrin (L-PRF), the present study aimed to evaluate the effectiveness of T-PRF and L-PRF, based on clinical and radiographic evaluations, in the management of intra-bony defects
probing pocket depth (PPD) and clinical attachment level (CAL) values in both the T-PRF and L-PRF groups showed statistically significant improvements in the intra-group comparisons at different time intervals, whereas the results were non-significant in intergroup comparisons (Table 2)
Summary
Periodontitis is a multifactorial inflammatory disease destroying the hard and soft tissues of the periodontium.[1] The goal of any periodontal therapy is to reduce inflammation, decrease probing pocket depth (PPD), and increase clinical attachment level (CAL). For the restoration of this lost bone, various bone graft materials and regenerative techniques have been implemented previously.[4] Later on, research efforts shifted toward platelet concentrates because of the acceleration of wound healing and stimulation of adjacent cells for the restoration of the lost periodontium
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