Abstract
BACKGROUND: Chronic kidney disease (CKD) is a clinical syndrome due to irreversible renal dysfunction leading to excretory, metabolic & synthetic failure culminating into accumulation of non-protein nitrogenous substances and present with various clinical manifestations. Since kidney competes with iodide clearance, Thyroid hormonal system is affected. So its important to evaluate for thyroid function in CKD patients. AIMS AND OBJECTIVES: To evaluate thyroid function in patients with chronic kidney disease and its correlation with severity of CKD. MATERIALS AND METHODS: An cross sectional study of 50 cases of chronic kidney disease. A detailed history, a thorough clinical and general examination, blood investigations (serum creatinine, thyroid profile, t3, t4, TSH).Data collected and statistically analyzed. RESULTS: Out of these 50 patients of chronic kidney disease who are on conservative management & fulfilling the inclusion criteria, 23 patients (46%) are euthyroid, 17 patients (34%) had subclinical hypothyroidism,10 patients (20%) had overt hypothyroidism. CONCLUSION: it is found that reduced eGFR is associated with an increased prevalence of SCH and clinically overt hypothyroidism. Physicians treating patients with CKD should be aware that CKD and hypothyroidism may shows overlapping symptom complexes & should go for an prompt evaluation of thyroid function in suspected cases.
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