Abstract
AbstractPrevious research has shown that the chorioallantoic membrane (CAM) of a fertile hen's egg can be a useful model for predicting eye irritation potential. However, the specific test procedure utilized will affect the degree of correlation between the CAM response and the results from the standard Draize rabbit eye irritation test. We studied how various components of a standard CAM assay, such as age of CAM and the endpoint evaluated, have an impact on the relationship of the CAM response to the in vivo eye response. These studies suggested the basis for a new CAM assay procedure that improves the correlation with the in vivo test. Herein is described an assay method that involves treating a 14-day-old CAM and evaluating the vascular changes that occur 30 min following treatment. This method is referred to as the CAM vascular assay (CAMVA). The CAMVA is shown to produce fewer false-positive responses than previously described CAM procedures and is especially effective at differentiating irritants f...
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