Abstract
Myrna T Mendoza1*, Marc Agnew M Cajucom2, Jill R Itable1,3 and Rosally P Zamora1,4 1Section of Infectious Diseases, Department of Medicine, University of the Philippines-Philippine General Hospital, Philippines 2Microbiology Laboratory, Medical Research Laboratories, Department of Medicine, University of the Philippines-Philippine General Hospital, Philippines 3Section of Infectious Diseases, Department of Internal Medicine, San Pedro Hospital, Davao City, Philippines 4Department of Internal Medicine, East Avenue Medical Center, Quezon City, Philippines *Corresponding author: Myrna T Mendoza, Section of Infectious Diseases, Department of Medicine, University of the Philippines-Philippine General Hospital, Philippines, Tel: +63-2-5251062; E-mail: myrnatmendoza@yahoo.com
Highlights
In a developing country with high prevalence of pulmonary tuberculosis (PTB) like the Philippines, a reliable low cost diagnostic tool for the detection of Mycobacterium tuberculosis (M. tuberculosis) in clinical specimens is needed [1]
This study aims to compare the performance of the microscopic observation drug susceptibility (MODS) assay in the detection of M. tuberculosis and MDR-TB from sputum specimens with the standard egg-based solid culture medium (Lowenstein Jensen) and the liquid MB BacT automated culture system
Study population and setting Sputum specimens were gathered from patients suspected to have pulmonary tuberculosis (PTB) were screened from two study populations: patients at the outpatient clinics of the departments of internal medicine, family medicine and TB DOTS clinic of the University of the Philippines-Philippine General Hospital (UP-PGH) and from patients referred by the Department of Health’s Programmatic Management of Drug-Resistant tuberculosis (PMDT)
Summary
In a developing country with high prevalence of pulmonary tuberculosis (PTB) like the Philippines, a reliable low cost diagnostic tool for the detection of Mycobacterium tuberculosis (M. tuberculosis) in clinical specimens is needed [1]. Case detection is mainly based on sputum microscopy, a diagnostic tool that has low sensitivity [2,3]. DST results are released 3 weeks after a positive specimen is detected. M. tuberculosis culture and DST results are known to the clinicians in about 3 months after a positive specimen is submitted. This is a long delay in the proper management of a patient with MDR-TB
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