Abstract

The stability of polymer-coated silica-based packing materials for high-performance liquid chromatography was examined. Linear relationships between the pH of the eluent and the logarithm of the concentration of silicic acid dissolved in the effluent, log C SIL, were observed, and the slope of the lines was dependent on the surface properties of the packing materials. A lower solubility was observed for polymer-coated silica and glass beads in comparison with common porous bare silica beads. A linear relationship between the specific surface area and log C SIL was observed for porous silica beads, and the plots for polymer-coated silica and glass beads deviated from linearity.

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