Abstract
Objective: The aim of this study was to determine the serum visfatin, eotaxin and fetuin-A levels in patients with normal BMI and overweight type 2 diabetes mellitus (T2DM).
 Material and Method: This study perform in 30 T2DM patients and in 20 healthy subjects. Test subjects were divided into four groups as two diabetics and two controls. Diabetics with a body mass index (BMI) of 26.2-29.9 kg/m2 were included in the overweight diabetic group (OD), and those with a body mass index of 20.9-24.9 kg/m2 were included in the normal BMI diabetic group (ND). The volunteers in the control group were also divided into two groups as overweight (OC) and normal BMI (NC). Smoking and alcohol users were not included in the study. In addition, patients with significant diabetic complications such as retinopathy, hypertension, neuropathy, renal failure, and cardiovascular disease were excluded from the study. The serum visfatin eotaxin and fetuin-A levels were measured using the ELISA method. The Mann-Whitney U test was used to compare the data of the groups, while Spearman’s analysis was applied for the correlations.
 Results: The visfatin levels of the OD and ND were significantly higher compared to those of their control groups (p
Highlights
Type 2 diabetes mellitus (T2DM) is accepted as one of the most prominent metabolic diseases of the 21st century [1]
Diabetics with a body mass index (BMI) of 26.2-29.9 kg/m2 were included in the overweight diabetic group (OD), and those with a body mass index of 20.9-24.9 kg/m2 were included in the normal BMI diabetic group (ND)
Serum visfatin and eotaxin levels are high in patients with T2DM, and this elevation is dependent on BMI
Summary
Type 2 diabetes mellitus (T2DM) is accepted as one of the most prominent metabolic diseases of the 21st century [1]. The pathogenesis of T2DM is not completely known, it is thought to be due to the interactions of genetic, environmental, and behavioral risk factors [4]. Urbanization, longevity, physical inactivity, unhealthy diet, smoking, drinking alcohol, and obesity all contribute to the development of T2DM [5]. A significant number of patients with T2DM are obese and the incidence of diabetes is closely related to the increase in obesity prevalence [6]. Obesity to the development of the disease in approximately 55% of patients with T2DM [7]
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