Abstract
Colorectal cancer one of the most common and aggressive tumor diagnosed in humans. The potential rolehas been suggested that circulating microRNAs assuring diagnostic markers for early detection of colorectalcancer .Hereabouts, this investigation intends to study the performance of miRNA-21 in CRC. Fifty bloodsamples were collected from individuals with colon cancer who enrolled in the Teaching Laboratories ofthe Medical City/Baghdad from June 2018 to September 2019. Taq Man microRNA Real-time PCR wasutilized to recognize the expression of miRNA-21 in the patient’s plasma. Representative in the expressionof miRNA-21 by gender and pathological grading were not statistically important (P>0.05). Moreover,alterations in the expression of miRNA-21 amongst patients and control were significances statistically(P<0.05). While a higher risk of the disease was associated with high miRNA-21 and correlated with poorprognosis. The AUC for miRNA-21 was 0.657. The optimal cut-off value was 1.961-fold with sensitivityand specificity 64%, 68% respectively. In Conclusion, the high miRNA-21 expression might be a prognosticmarker of colon cancer patient consequently; high expression of miRNA-21 was associated with poorprognosis of patients with colorectal cancer.
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