Evaluation of the role of ACT1 gene polymorphism in seborrheic dermatitis: a case–control study

Abstract

ObjectivesThis study aims to assess the role of ACT1 gene polymorphism in seborrheic dermatitis (SD).BackgroundSD is a common inflammatory skin disease. However, the pathogenesis is poorly understood. Recently, some gene mutations had been linked to SD.Patients and methodsIn all, 90 participants were included in a case–control study, which included 45 SD patients diagnosed by history and clinical examination and 45 healthy controls matching the cases in age and sex. Severity of SD was assessed using Seborrheic Dermatitis Area and Severity Index. Assessment of ACT1 (tumor necrosis factor receptor-associated factor 3 interacting protein 2), rs13210247, and gene polymorphism was done by using the TaqMan allelic discrimination assay technique (real-time PCR).ResultsThe study revealed a significant difference between SD patients and controls regarding ACT1 (tumor necrosis factor receptor-associated factor 3 interacting protein 2), rs13210247, gene polymorphism as the GG genotype was significantly higher in patients than controls. The presence of G allele had a twofold increased risk for the occurrence of diseases. The presence of GG genotype increased the risk for disease eight times than other genotypes.ConclusionThis is the first case–control study showing that the ACT1 gene might have a role in the pathogenesis of SD.