Evaluation of the Rheologic and Physicochemical Properties of a Novel Hyaluronic Acid Filler Range with eXcellent Three-Dimensional Reticulation (XTR™) Technology.

Giovanni Salti,Salvatore Piero Fundarò

doi:10.3390/polym12081644

Abstract

Soft-tissue fillers made of hyaluronic acid and combined with lidocaine have recently become a popular tool in aesthetic medicine. Several manufacturers have developed their own proprietary formulae with varying manufacturing tools, concentrations, crosslinked three-dimensional network structures, pore size distributions of the fibrous networks, as well as cohesivity levels and rheological properties, lending fillers and filler ranges their unique properties and degradability profiles. One such range of hyaluronic acid fillers manufactured using the novel eXcellent three-dimensional reticulation (XTR™) technology was evaluated in comparison with other HA fillers and filler ranges by an independent research laboratory. Fillers manufactured with the XTR™ technology were shown to have characteristic rheological, crosslinking and biophysical factors that support the suitability of this filler range for certain patient profiles.

Highlights

Hyaluronic acid (HA)-based hydrogels have become the most commonly used soft-tissue fillers for facial rejuvenation [1]
Manufacturers have supplemented these characteristics by introducing novel HA filler formulations with the aim of stabilizing, increasing tissue longevity and enhancing their tolerability [3]
The following results reflect the analyses of the physicochemical and mechanical properties of the selected injectable crosslinked HA gels based on previously developed pre-specified protocols

Summary

Introduction

Hyaluronic acid (HA)-based hydrogels have become the most commonly used soft-tissue fillers for facial rejuvenation [1]. Manufacturers have supplemented these characteristics by introducing novel HA filler formulations with the aim of stabilizing, increasing tissue longevity and enhancing their tolerability [3]. Distinct proprietary formulae have been developed using various manufacturing tools, HA concentrations, crosslinked three-dimensional network structures, pore size distributions of the fibrous HA networks, cohesivity levels and rheological properties. These properties influence the physical properties of the HA filler product and their variants, often referred to as ‘ranges’, which in turn affect their clinical effects.

Methods

Discussion

Conclusion