Abstract
Background/aim This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients.Materials and methods Twenty-four patients with unilateral XFS, 20 patients with bilateral XFS, and 23 healthy subjects were enrolled in this study. Eyes with XFS were compared with both fellow eyes and age-matched control subject eyes in terms of mean and segmental RNFL thickness and minimum, mean, and segmental GCC thickness. Results In the bilateral XFS group, minimum GCC of the right eye (75.80 ± 11.6 µm) was significantly thinner compared with the right eyes of the control group (81.83 ± 6.6 µm) (P < 0.05). Also, superior RNFL was thinner in the right eye (106.90 ± 16.7 µm) compared with left eye (114.15 ± 18.1 µm) in the bilateral XFS group (P < 0.05). No significant differences in the unilateral XFS group were detected in GCC and RNFL analysis.Conclusion Minimum GCC value may be the first parameter affected in the conversion of XFS to exfoliative glaucoma followed by RNFL changes.
Highlights
Exfoliation syndrome (XFS), which is characterized by the accumulation of a distinctive fibrillar extracellular material in the anterior segment of the eye, is the most common cause of secondary open-angle glaucoma, especially in the elderly population
Background/aim: This study aimed to evaluate retinal nerve fiber layer (RNFL) and ganglion cell complex (GCC) thicknesses using spectral domain optical coherence tomography (SD-OCT) in both unilateral and bilateral exfoliation syndrome (XFS) patients
No significant differences in the unilateral XFS group were detected in GCC and RNFL analysis
Summary
Exfoliation syndrome (XFS), which is characterized by the accumulation of a distinctive fibrillar extracellular material in the anterior segment of the eye, is the most common cause of secondary open-angle glaucoma, especially in the elderly population. XFS has been shown to cause glaucomatous damage by raising intraocular pressure (IOP) and by diminishing the blood flow in the retina, optic nerve head, and choroidal and retrobulbar vessels [3,4,5,6]. In this context, patients with XFS are at risk of developing glaucoma [7].
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