Evaluation of The Renal Function in The Intrauterine Growth Restricted Rats and The Effect of Maternal Glucocorticoids

Abstract

The purpose of the study was to determine the effect of maternal glucocorticoids on experimental growth retardedrats and the effect of maternal undernutrition in different gestation periods for function of the kidney. This studyhad two sections. In the first section, 5 groups were formed. 10g/d diet was given in the 1st, 2nd, and 3rd trimesterand throughout the pregnancy period. The control group was fed a normal diet. In the second section, 3 groupsformed and all the rats take 10 g/d diet throughout pregnancy period. To determine the effect of endogenousglucocorticoids first group was treated with metyrapone, second group metyrapone+dexamethasone and theplacebo injected saline until 14 days of pregnancy. The offsprings body and kidney weights were detected inthe 0, 3rd and 20th weeks of age. Renal extraction functions and blood pressures from tail detected in the 20thweek of age. Urinary excretion and glomerular filtration rate were low in rats that had dietary restriction in thelast trimester. The glomerular filtration rates were found to be low in the group that had diet restriction duringthe whole pregnancy. Blood pressure values were found to be lower in the group that had diet restriction duringtheir pregnancy compared to the control group. Kidney weights were similar in all groups in the first phase. Itwas observed that renal excretion functions were preserved in the group receiving metyrapone treatment, butthere was no statistically significant difference between the results. Low blood pressures were normalized withmetyrapone treatment. The kidney sizes at the 20th week of the rats which receiving metyrapone treatment werefound to be smaller than those receiving physiological saline solution. Food restriction destroys renal functionsbut no effects with high blood pressure in adulthood. Glucocortiod exposure in pregnancy may reduce renaldevelopment.