Abstract
Background and aims. Oral lichen planus (OLP) is an immunologic disorder. A large number of studies have reported that lipid rafts have a key role in receptor signaling of lymphocytes. Here, we explore the potential of lipid rafts as targets for the development of a new class of agents to down-modulate immune responses and treat autoimmune diseases.Materials and methods. The present cross-sectional study evaluated 88 patients referring to the Department of Oral Medicine in 3 groups (Group 1: erosive OLP; Group 2: non-erosive OLP; Group 3: healthy). A total of 3 mL of blood sample was taken from each subject and the serum levels of cholesterol, triglycerides, HDL and LDL were determined. The mean outcomes of each group were compared with each other and analyzed two by two.Results. The results of statistical analyses showed no significant differences in mean HDL and LDL serum levels between the three groups. The results of post hoc LSD test showed that mean serum levels of subjects with erosive and non-erosive lichen planus were higher than those in healthy subjects. In relation to triglyceride serum levels, the mean serum levels of triglycerides were higher in erosive and non-erosive OLP patients compared to healthy subjects.Conclusion. Triglyceride and cholesterol can be considered to have a critical role in the incidence of lichen planus and in its manifestations as predisposing factors.
Highlights
Oral lichen planus is an immunologically based, chronic, inflammatory mucocutaneous disorder of undetermined etiology
The results of statistical analyses showed no significant differences in mean high-density lipoproteins (HDL) and low-density lipoproteins (LDL) serum levels between the three groups
The aim of this study was to evaluate the relationship between serum lipid profile and oral lichen planus; in case of any possible positive relationship, controlling these serum elements would decrease the incidence of oral lichen planus
Summary
Oral lichen planus is an immunologically based, chronic, inflammatory mucocutaneous disorder of undetermined etiology. The overall prevalence of lichen planus in the general population is about 0.1‒4% It generally occurs more commonly in females at a ratio of 3:2, and most cases are diagnosed between the ages of 30 and 60, but it can occur at any age. It is believed to result from an abnormal cell-mediated immune response with infiltrating cell population composed of both T4 and T8 lymphocytes in the basal epithelial cells. They are recognized as foreign because of changes in the antigenicity of their cell surfaces.[1]. The results of post hoc LSD test showed that mean serum levels of subjects with erosive and non-erosive lichen planus were higher than those in healthy subjects.
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