Abstract
Introduction: Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Recently, neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an inflammatory index in many disorders such as CKD. Several studies also have shown the anti-inflammatory effects of vitamin D, and scientists believe that we must prevent vitamin D deficiency in CKD patients. Vitamin D supplementation may decrease mortality and morbidity in end-stage renal disease (ESRD) patients. Objectives: There are few studies on the association between serum 25-hydroxy vitamin D levels and NLR in ESRD patients. Therefore, we tried to evaluate this correlation, hoping to be a key for more researches. Patients and Methods: We enrolled 140 ESRD hemodialysis patients in a cross-sectional study and evaluated the correlation of NLR with serum 25-hydroxy vitamin D levels and some demographic factors in these patients. Results: Our results showed a statistically significant negative correlation between NLR and serum 25-hydroxy vitamin D levels (P=0.010, r= -0.216). However, other variables such as disease duration and age had no correlation with NLR (P=0.649, r= - 0.039 and P=0.781, r= - 0.024, respectively). We also used a linear regression test to check any confounder associated with NLR, and the regression was only significant for serum 25-hydroxy vitamin D levels (P=0.011, B=-0.009). Conclusion: Based on the results, serum 25-hydroxy vitamin D levels can be considered a predictor for NLR in hemodialysis patients.
Highlights
Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients
We used a linear regression test to check any confounder associated with neutrophil-to-lymphocyte ratio (NLR), and the regression was only significant for serum 25-hydroxy vitamin D levels (P = 0.011, B=-0.009)
In a study on 140 hemodialysis patients, we found a statistically significant negative correlation between NLR and serum 25-hydroxy vitamin D levels (P = 0.010, r = -0.216)
Summary
Chronic low-grade inflammation is a comorbid factor in Chronic kidney disease (CKD), and especially in chronic dialysis patients. Neutrophil-to-lymphocyte ratio (NLR), which is very available and affordable, has emerged as an inflammatory index in many disorders such as CKD. Chronic kidney disease (CKD) is one of these diseases. It is a progressive and non-reversible disorder that is a health problem worldwide. Chronic subclinical inflammation is regarded as a comorbid factor in CKD, and especially in chronic dialysis patients [4]. Neutrophil-to-lymphocyte ratio (NLR) has emerged as an inflammatory marker for several chronic subclinical inflammatory diseases such as CKD [5,6].
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