Evaluation of the relationship between lactate dehydrogenase level and clinical status of patients with COVID-19 in terms of disease severity in patients admitted to Shahid Sadoughi Hospital in Yazd

Abstract

There are many evidences suggesting that the serum lactate dehydrogenase (LDH) levels reflect the extent of various pathophysiological processes. However, the current information about dynamic change of LDH in COVID-19 pneumonia has not been well investigated. This study aimed to evaluate the relationship between LDH level and clinical status of patients with COVID-19 in terms of disease severity in patients. This study included all COVID-19 patients admitted to the wards and ICU of Shahid Sadoughi Hospital in Yazd and the sampling method in this study is census. Patients' information will be extracted from their file and entered into a predefined checklist. This information was entered into SPSS.V21 software. Of 4346 patients whose LDH test is available, 2364 (54.4%) are male and 1982 (45.6%) are female. 487 (11.2%) of patients in intensive care unit and 3859 (88.8%) were hospitalized in other wards. The mean serum LDH level was significantly different between patients admitted to the intensive care unit and other wards of the hospital (pvalue <0.001). Increased LDH serum levels were associated with poor prognosis in patients with COVID-19.