Abstract
Background & Objective:Nowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors. This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer.Methods:The included population consisted of 40 confirmed cases of female breast cancer (including 20 patients with breast cancer along with axillary lymph node metastasis and 20 patients without axillary lymph node metastasis). Expression of Villin and Gelsolin genes was evaluated using Real-time PCR and pre-designed primers.Results:The mean expression level of Villin in groups with and without axillary lymph node metastasis was 3.33±1.35 and 0.87±0.88, respectively (P<0.001). The mean Gelsolin expression levels in both groups (with and without axillary lymph node metastasis) were 4.13±2.40 and 1.00±0.35, respectively (P<0.001). The significant relationships were independent of individuals’ age.Conclusion: Patients with axillary lymph node metastasis may express significant higher level of Villin and Gelsolin genes.
Highlights
ObjectivesThis study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer
Background & ObjectiveNowadays, actin-binding proteins such as Villin and Gelsolin have been considered to be associated with aggressive tumors
A 92.5 kDa protein, is a crucial member of actin-binding proteins generally found in the microvilli of brush borders of epithelial linings of different gastrointestinal organs such as stomach, pancreas gland, bile ducts and intestines; as well as corresponding adenocarcinomas [10, 11]
Summary
This study mainly aims to determine the relationship between Gelsolin and Villin genes expression and metastasis of axillary lymph nodes in patients with breast cancer
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have