Abstract
Introduction: Complete thrombotic occlusion of a major epicardial coronary artery is the common pathophysiological mechanism of acute ST-segment elevation myocardial infection (STEMI). Intravascular thrombosis is associated with poor prognosis in patients with STEMI. Methods:In this study, we enrolled 400 patients with STEMI undergoing PPCI . Based on TIMI ratings of the patients and reviewing their angiographic film, they were divided into two groups with high thrombus burden and low thrombus burden. Then, Monocytes were measured in two groups with higher and lower thrombus. Results:A total of 400 patients with STEMI (mean age of 58.71 ± 12.31, 80.5% male) who underwent PPCI enrolled in this study. There were no significant differences between the low thrombus and high thrombus group in In terms of diabetes, high blood pressure, previous history of MI and cardiac troponin levels, However, patients with high thrombus had lower EF .(p value < 0.001). Based on the multivariate analysis result, the amount of circulating monocytes during hospitalization is an independent factor in predicting the rate of thrombosis in angiography. Odds ratio= 3.099 , p value=0.019 .Analysis of the receiver-operating characteristic found an optimal monocyte count cut-off value to be ≤0.60*104 in predicting a high thrombus burden score. Conclusions: The results of the study showed that the number of monocytes is a predicator of high intracoronary thrombus burden in patients with acute STEMI and patients can be treated with antithrombotic treatments.
Highlights
Complete thrombotic blockage of a major epicardial coronary artery is the common pathophysiological mechanism of acute ST-segment elevation myocardial infection (STEMI)
We assessed the association of monocyte count and angiographic thrombosis burden in STEMI patients
Our study indicated that higher monocytes count is a predictor of high intracoronary thrombus burden in patients with acute STEMI, and patients can be treated with antithrombotic treatments
Summary
Complete thrombotic blockage of a major epicardial coronary artery is the common pathophysiological mechanism of acute ST-segment elevation myocardial infection (STEMI). Conclusions: Our study indicated that higher monocytes count is a predictor of high intracoronary thrombus burden in patients with acute STEMI, and patients can be treated with antithrombotic treatments. 1. Complete obstruction of the thrombus of the major coronary arteries of the epicardium is a common pathophysiological mechanism of myocardial infarction (MI) with an exacerbated ST-segment elevation myocardial infection (STEMI).[2] The main pathophysiology of the STEMI is the formation of intravascular thrombus due to rupture of the atherosclerotic plaque and cessation of coronary blood flow. Clinical studies have demonstrated that the amount of intravascular thrombus plays a key role in low thrombolysis in myocardial infarction (TIMI) and impaired myocardial perfusion.[4] Identifying the correlation between blood cell-dependent biomarkers and blood flow status during PPCI is a common focus in research.[5]. The first stage is dominated by Ly-6chigh monocytes and the one is dominated by Ly-6clow monocytes.[6]
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