Abstract
Background and purpose: Doxorubicin (Adriamycin) a chemotherapeutic agent belonging to Anthracycline family, is frequently used in the treatment of cancers. Despite its effectiveness, a vast variety of adverse effects have been attributed to this drug with the suggested mechanisms of inducing ROS and mitochondrial damage causing hepatic and cardiac toxicity. In addition to cancer cells, doxorubicin also interferes with the normal cell genome and consequently induce secondary malignancy. Simvastatin, Simvastatin is a fat-lowering drug that has cytoprotective and antioxidant effects. This study attempts to examine the protective effect of simvastatin against doxorubicin induced genotoxicity in the culture medium using the Comte method. Materials and Methods: For this purpose, we measured the DNA damage level with comet assay in HepG2 and HGF cells treated with doxorubicin and simvastatin in pre-treatment condition. Results were reported based on mean ± SEM. p<0.05 considered as significant deference. The mean values were compared using SPSS and ANOVA test followed by tukey posttest.
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