Abstract
Objective: This work was aimed to investigate the prophylactic and therapeutic role of Indian shrimp in aluminum chloride-induced Alzheimer’s disease (AD) in rats.
 Methods: The male Wistar rats were selected and divided into six groups. Group I received distilled water, Group II received AlCl3 ( 100 mg/kg, p.o.), Group III received rivastigmine (1 mg/kg, p.o.), Group IV received AlCl3 + shrimp powder (200 mg/kg, p.o), and Group V received AlCl3 + shrimp powder (400 mg/kg, p.o) for 60 days. At the end of the study, various parameters such as behavioral and biochemical investigations were assessed.
 Results: The result of the study shows that the shrimp (400 mg/kg) has better effect on the treatment of aluminum chloride-induced AD in rats. It showed a remarkable improvement in the behavioral and biochemical parameters, and the result of histopathology study shows that the hippocampus region of brain tissue recovered as compared with control.
 Conclusion: From this study, it is evident that dietary intake of shrimp can help to inhibit oxidative stress produced due to the accumulation of AlCl3 in the brain and used as a prophylactic for AD.
Highlights
Alzheimer’s disease (AD) is a neurodegenerative disorder [1] which is known to produce dementia and behavioral deterioration
The results indicated that the administration of AlCl3 induced dementia in experimental rats and the biochemical changes occurred in rats resembled like AD produced in humans
Morris water maze test AlCl3 administered animal groups exhibited an increase (p
Summary
Alzheimer’s disease (AD) is a neurodegenerative disorder [1] which is known to produce dementia and behavioral deterioration. The early symptom is the short-term memory loss as the disease progresses more severe problems occurs such as language disorientation [2], mood swing, and behavioral issues if it is untreated gradually, the bodily functions are lost leading to death. Accumulation of neurotoxic amyloid-β (Aβ) oligomers intracellular and extracellular found in the brain of Alzheimer’s [3]. The brains of the Alzheimer’s may be characterized by neurofibrillary tangles and senile plaques and loss of cholinergic neurons in the basal forebrain. There is no recognizable cure available for AD, the cause and the factors that underlie the progression [4,5,6]
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