Abstract
Objectives: To evaluate the effect of lymphadenectomy on clinical outcome in patients with low-grade serous ovarian cancer (LGSOC). Methods: The study mainly included patients with LGSOC whose initial treatment was surgery. Disease-free survival (DFS) and overall survival (OS) was selected as primary endpoints. Propensity score matching (PSM) algorithm was used to balance the basic characteristics of patients with lymphadenectomy or not, and the Kaplan-Meier analysis was used to evaluate the impact of clinical prognosis. Finally, univariate and multivariate Cox proportional hazards regression analyses were performed to analyze the high-risk factors associated with clinical prognosis. Results: A total of 147 women from four medical centers were enrolled. In the before matching cohort, 101 (68.7%) patients underwent lymphadenectomy. Fifty-two (35.4%) patients experienced recurrence, and 25 (17%) patients died. Kaplan-Meier analysis showed no significant difference in DFS (p=0.058) and OS (p=0.067) in the after-matching cohort. Cox proportional hazard regression analysis showed that age (p=0.012), FIGO stage (p=0.031), and effective cytoreductive surgery (p=0.044) were three high-risk factors associated with recurrence. Age (p=0.031) and effective cytoreductive surgery (p=0.009) were two high-risk factors associated with death. Conclusions: Lymphadenectomy seems not to provide a significant benefit in neither DFS nor OS in our study. Age, the FIGO stage, and effective cytoreductive surgery are high-risk factors associated with clinical prognosis in LGSOC patients. Objectives: To evaluate the effect of lymphadenectomy on clinical outcome in patients with low-grade serous ovarian cancer (LGSOC). Methods: The study mainly included patients with LGSOC whose initial treatment was surgery. Disease-free survival (DFS) and overall survival (OS) was selected as primary endpoints. Propensity score matching (PSM) algorithm was used to balance the basic characteristics of patients with lymphadenectomy or not, and the Kaplan-Meier analysis was used to evaluate the impact of clinical prognosis. Finally, univariate and multivariate Cox proportional hazards regression analyses were performed to analyze the high-risk factors associated with clinical prognosis. Results: A total of 147 women from four medical centers were enrolled. In the before matching cohort, 101 (68.7%) patients underwent lymphadenectomy. Fifty-two (35.4%) patients experienced recurrence, and 25 (17%) patients died. Kaplan-Meier analysis showed no significant difference in DFS (p=0.058) and OS (p=0.067) in the after-matching cohort. Cox proportional hazard regression analysis showed that age (p=0.012), FIGO stage (p=0.031), and effective cytoreductive surgery (p=0.044) were three high-risk factors associated with recurrence. Age (p=0.031) and effective cytoreductive surgery (p=0.009) were two high-risk factors associated with death. Conclusions: Lymphadenectomy seems not to provide a significant benefit in neither DFS nor OS in our study. Age, the FIGO stage, and effective cytoreductive surgery are high-risk factors associated with clinical prognosis in LGSOC patients.
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