Abstract
Purpose: To evaluate the potential chondroprotective activity of a natural rooster comb extract (Hyal-Joint®) containing mainly Hyaluronic Acid (HA) and Dermatan Sulfate (DS) at approximately 4:1, respectively, in comparison with Hyaluronic Acid (HA). Methods: Three in vitro assays were performed to determine the putative activity of Hyal-Joint®. Its effect on the synthesis of endogenous AH was measured in synoviocytes from osteoarthritic patients (n=3) and was compared to HA from fermentation and HA from natural origin. The effect on catabolism (matrix metalloprotease activity and Interleukin-6 production) was determined by using human osteoarthritic chondrocytes (n=4) stimulated with Interleukin-1ß (IL-1β) and treated with HA, DS and a mixture containing HA and DS in a 4:1 proportion. Results: In human synoviocytes, all 3 compounds exhibited a concentration-dependent effect. Cultures treated with Hyal-Joint® presented higher values of endogenous HA than the other two. This natural extract also showed inhibitory effects on catabolism, with a reduction of IL-6 levels and a synergistic action between HA and DS when given together to decrease metalloprotease activity. Conclusions: The present study indicates that Dermatan Sulfate could potentiate the chondroprotective activity of Hyaluronan. Thus, Hyal-Joint® may be a useful nutritional supplement for maintaining joint integrity and function.
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