Abstract
Objective: to evaluate the possibilities of ultrasound elastography for differentiation of reactive and lymphomatous superficial lymph nodes (LN).Materials and methods. The prospective study included 138 patients with enlarged superficial LN. Based on a previous histological examination, patients were divided into two groups: 1st group (n = 108) – patients with non-Hodgkin’s lymphomas and Hodgkin’s lymphoma; 2nd (n = 30) – patients with reactive (inflammatory) changes in superficial LN. All patients underwent ultrasound elastography of the enlarged LN using ARFI technology.Results. According to the results of ultrasound elastography, the average, minimum, and maximum shear wave velocities for enlarged LN in lymphoma (1st group) were 2.616 ± 0.684; 1.980 ± 0.557 and 3.351 ± 0.987 m / s, respectively; for LN with reactive changes (2nd group) – 1.704 ± 0.223; 1.414 ± 0.209 and 2.027 ± 0.261 m / s, respectively. Thus, the average, minimum, and maximum values of shear wave velocities significantly different between the groups (p ˂0.001). The cut off values of the average shear wave velocity in the differential diagnosis of lymphoma and hyperplasia are determined at the level of 2.05 m / s, with a sensitivity of 88.5 %, specificity of 100 %, and AUC of 0.942 (p ˂0.001).Conclusion. Ultrasound elastography demonstrated statistically significant differences in shear wave velocity in the enlarged superficial LN in lymphoma and in inflammatory processes that can be used as a preliminary non-invasive differential diagnosis of enlarged superficial LN in these conditions.
Highlights
Based on a previous histological exa mination, patients were divided into two groups: 1st group (n = 108) – patients with non-Hodgkin’s lymphomas and Hodgkin’s lymphoma; 2nd (n = 30) – patients with reactive changes in superficial lymph nodes (LN)
The cut off values of the average shear wave velocity in the differential diagnosis of lymphoma and hyperplasia are determined at the level of 2.05 m / s, with a sensitivity of 88.5 %, specificity of 100 %, and AUC of 0.942 (p0.001)
Liu L.J., Xu X.H., Yang Y.G. et al Value of virtual touch tissue quantification of acoustic radiation force impulse elastography in differential diagnosis of cervical lymph nodes
Summary
Ultrasound elastography demonstrated statistically significant differences in shear wave velocity in the enlarged superficial LN in lymphoma and in inflammatory processes that can be used as a preliminary non-invasive differential diagnosis of enlarged superficial LN in these conditions. Выявление и первоначальная дифференциальная диагностика измененных поверхностных ЛУ наиболее часто проводятся с использованием ультразвуковой диагностики в связи с доступностью, безопасностью и относительно низкой стоимостью данного метода [2, 5]. Точечная эластография сдвиговой волной (shear wave elastography) позволяет оценивать скорость сдви говой волны в зоне интереса, которую под контролем серошкальной эхографии мы можем установить в ин тересующий нас участок органа, ткани или образова ния [7]. Суть данной технологии заключается в том, что ультразвуковой датчик генерирует сфокусированные высокоинтенсивные кратковременные акустические импульсы и отслеживает распространение их для вы числения значения скорости сдвиговой волны, выра женного в м / с [9]. Цель исследования – оценить возможности точеч ной ультразвуковой эластографии в дифференциаль ной диагностике лимфопролиферативных и реактив ных изменений поверхностных ЛУ. Минимальные и максимальные показатели скорости сдвиговой волны у пациентов 1‐й и 2‐й групп
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