Abstract
Phillygenin is a bioactive intergradient in Osmanthus fragrans, a well-known food additive and Chinese traditional medicine. This study was to investigate the hepatoprotective effects and pharmacokinetics of phillygenin. The hepatoprotective effect of phillygenin was assessed in carbon tetrachloride- (CCl4-) intoxicated mice by monitoring levels of serum and tissue biomarkers. The pharmacokinetics of phillygenin was evaluated in the mouse after oral (po, 24 mg / kg) or intravenous (iv, 12 mg/kg) administration. Results showed that phillygenin has a great hepatoprotective effect on CCl4-induced liver injury in mice owing to its antioxidant activity and inhibition on cytochrome P450 2E1(CYP2E1). After oral administration, phillygenin was efficiently absorbed with the oral bioavailability of 56.4%. Two metabolites, hydroxylated and dimethylated phillygenin, were identified in mouse urine. These results suggested that phillygenin could be explored as new and potential natural antioxidants and hepatoprotective agents.
Highlights
Osmanthus fragrans is a plant belonging to the Oleaceae family [1], which has been cultivated and distributed in East Asia, spanning a large geographic region through China to Japan [2]
Our lab has found that Osmanthus fragrans flower extract (OFE) showed a great hepatoprotective effect on carbon tetrachloride- (CCl4-)induced hepatic injury mice [2]
The results demonstrated that both of phillygenin and ascorbic acid could eliminate DPPH and ABTS radicals in a dose-dependent manner
Summary
Osmanthus fragrans is a plant belonging to the Oleaceae family [1], which has been cultivated and distributed in East Asia, spanning a large geographic region through China to Japan [2]. Osmanthus fragrans flower is valued as an additive for tea and various foods and used as cosmetics for hair and skin and aromatic therapy [1]. Osmanthus fragrans flower has a wide range of pharmacological properties including antioxidation [3], neuroprotection [4], and antimicrobial effects [5]. Our lab has found that Osmanthus fragrans flower extract (OFE) showed a great hepatoprotective effect on CCl4-induced hepatic injury mice [2]. Phillygenin, extracted from Osmanthus fragrans flower for the first time by our group [6], has many medicinal properties. It can reduce blood lipid levels [7] and low density lipoprotein [8]. Phillygenin has many pharmacological activities, there is limited hepatoprotective information on phillygenin
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