Evaluation of the pancreatoprotective effect of algal extracts on Alloxan-induced diabetic rat

Abstract

PurposeDiabetes is a metabolic syndrome which is associated with the worldwide major public health problems. In the present research, with respect to the traditional and ethnic uses of Polycladia myrica and Halimeda opuntia algal extract for healing of diabetic diseases. Materials and methodsalgal extracts at 100 and 200 mg/kg was administered orally to Alloxan-induced diabetic rats once daily for 15 days. Serum glucose levels, Complete Blood Count (CBC) and Kidney function of rats were measured at the end of experimental. The liver function of the pancreas was also observed. ResultsThe preprandial and postprandial glucose levels in the group treated with algal extracts (100 and 200 mg/kg) were significantly reduced compared with those of the diabetes group. Additionally, the levels of CBC, kidney function and liver function in the 100 and 200 mg/kg algal extract were significantly different from those in the diabetes group. ConclusionThe results illustrated that, algal extracts at 100 & 200 mg/kg had the best capability to lower the levels of glucose and we can conclude that Halimeda extract is the best effective extract as preventive medication (pre-treatment) and the polycladia extract with concentration 100 is the best effective extract as medication (post-treatment).