Abstract
Purpose: We synthesized the linoleic acid derivative 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]octanoic acid (DCP-LA) with cyclopropane rings instead of cis-double bonds. Here, we introduce DCP-LA as a novel anti-dementia drug. Study section and results: DCP-LA selectively and directly activated protein kinase C-e (PKCe) to enhance the activity of presynaptic a7 acetylcholine (ACh) receptors by promoting receptor translocation to the cell surface and increasing presynaptic glutamate release. This action of DCP-LA caused a long-lasting facilitation of hippocampal synaptic transmission, which improved learning and memory impairments in animal models. Conclusion: DCP-LA could be developed as a promising anti-dementia drug, offering new hope for treating dementias including Alzheimer disease.
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