Abstract
To investigate the neurotoxic effects of strontium (Sr) compounds and Glycyrrhiza glabra (licorice, G. glabra). In this study, we conducted neurotoxicity assays on the human cortical neuronal cell line HCN-2 (CRL- 10742) to determine the potential neurotoxic effects of Sr and G. glabra. No significant decrease in HCN-2 cell viability was observed with longer Sr exposure or Sr concentrations up to 2000 ?g/mL. The IC < sub > 50 < /sub > values of Sr for 24 and 48 hours of exposure were > 2000 ?g/mL, and 936.9 ± 0.09 ?g/mL for 72 hours. However, we observed a significant reduction in HCN-2 cell viability with longer exposure and higher concentrations of G. glabra. The IC < sub > 50 < /sub > values of G. glabra for 24, 48, and 72 hours were 545.1 ± 0.03 ?g/mL, 398.1 ± 0.03 ?g/mL, and 393.3 ± 0.02 ?g/mL, respectively. Additional studies are needed to further investigate the neurotoxicity of Sr and G. glabra, and elucidate the pathway by which these compounds exert their therapeutic effects in pathological conditions.
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