Abstract
Nano-TiO2 is widely applied in the automobile exhaust hose reels as a catalyst to reduce oxynitride emissions, including nitric oxide (NO). In the biomedicine field, NO plays an important role in vasodilation and edema formation in human bodies. However, the deswelling activity of nano-TiO2 has not been reported. Here, we demonstrated that nano-TiO2 can significantly degrade the production of NO in LPS-induced RAW264.7 mouse macrophages. Further study indicated that nano-TiO2 exhibited an effect on vascular permeability inhibition, and prevented carrageenan-induced footpad edema. Therefore, we prepared a nano-TiO2 ointment and observed similar deswelling effects. In conclusion, nano-TiO2 might act as a novel deswelling agent related with its degradation of NO, which will aid in our ability to design effective interventions for edema involved diseases.
Highlights
Nitric oxide is a by-product of combustion of the substances in the air, and it is abundant in automobile engines
Nano-TiO2 is demonstrated to be active on nitric oxide (NO) absorption in the air
RAW264.7 mouse macrophages to investigate the effects of nano-TiO
Summary
Nitric oxide is a by-product of combustion of the substances in the air, and it is abundant in automobile engines. Most reports show that NO can be broke into N2 and O2 by nano-TiO2 as a catalyst with the help of UV light and sensible light [1,2]. NO, known as an endothelium-derived relaxing factor (EDRF), is a powerful vasodilator with a short half-life of a few seconds in the blood. The endothelium of blood vessels uses NO to signal the surrounding smooth muscle to relax, resulting in vasodilation [3,4,5]. We examined whether nano-TiO2 might act as a deswelling material. To gain insights into the molecular mechanism, we further investigated the effects of nano-TiO2 on degrading. We believe that further study on nano-TiO2 will aid in our ability to design effective interventions and treatments for edema involved diseases.
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