Abstract
Natural products from flora have been largely used in popular medicine for centuries. The development of tests to measure mutagenic activity of chemicals has been helpful to increase security and safety of different compounds, including natural products. The present study was carried out to evaluate the mutagenic effects of a water-ethanolic crude extract obtained from Pothomophe umbellata aerial parts on Rattus norvegicus cells in vivo, using the comet (SCGE) and micronucleus (MN) assay. Animals were treated orally with three different concentrations of the extract (500, 1000 and 1500 mg/ kg) and sacrificed 24 hours after treatments. The results have shown that the extract of P. umbellata did not induce statistically significant increases in the average numbers of DNA damage in hepatic cells and MN in bone marrow cells. However, a significant increase of DNA damage in peripheral blood cells has been noticed.
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