Abstract
Aims: Poultry industry in Nigeria has recorded considerable expansion in recent times but not without poultry diseases as one of the major threats to boosting poultry production. Protozoa cause the majority of parasitic infections and cause high mortalities. Parasitic diseases such as coccidiosis are of particular importance because of their high incidence in poultry occasioned by the tropical environmental conditions under which the farmer operates. The resistance to common anticoccidial drugs has led to exploring other natural sources for prophylaxis and therapy. This research evaluated the therapeutic efficacies of Annona muricata at different dosages of 100, 125, 165mg/kg body weight using 120 broilers at 4 weeks of age. 
 Place and Duration of Study: Animal Parasitology and Microbiology Research Unit, Department of Animal Production and Health, Federal University of Technology, Akure, Nigeria, between September and December, 2022.
 Methodology: 120 broilers of 4 weeks old were used for this study using completely randomized study design. The birds were infected with sporulated Eimeria tenella oocysts at week 4. Treatment with ethanolic extract of Annona muricata was administered orally at week 5 using different dosages of 100, 125, 165mg/kg body weight for five consecutive days. Treatment commenced after the isolation of Eimeria oocysts in the faeces and onset on coccidial clinical signs as parameters to confirm manifestation of the infection. Blood parameters, faecal oocysts count and biochemical assays were conducted.
 Results: Results revealed that therapeutic administration of Annona muricata leaf extracts at minimum dose 100mg/kg body weight had significant reduction (P<0.05) on excreted Eimeria oocysts counts without any significant deviation from normal haematological and biochemical indices of the broilers.
 Conclusion: This study suggests the use of Annona muricata in the treatment of coccidiosis in broiler chickens. It is therefore recommended that its extracts be further explored for actual phytochemical constituents responsible for the displayed anticoccidial properties.
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